HPV45 and HPV81 are low-risk types of HPV infection, and their positivity is mainly related to high-risk sexual behavior, sharing of personal items, and autoimmune factors. 1. High-risk sexual behavior: For those who have multiple sexual partners or high-risk sexual partners, having high-risk sexual behavior with an HPV-infected partner, such as not using a condom, may increase the risk of low-risk HPV infection. 2. Sharing personal items: For HPV45, HPV81 and other two types of low-risk HPV infection, it is likely to be infected through the sharing of personal items, such as common swimming, sharing towels, toilets, toothbrushes and so on, thus causing indirect infection. 3. Autoimmune factors: If the patient’s immune system has problems (such as HIV infection, AIDS, taking immunosuppressive drugs, etc.), it will cause the body’s immunity to the infection to decline, which in turn increases the risk of low-risk HPV infection. Patients who are positive for HPV45 and HPV81 are advised to go to the hospital for timely consultation, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy.