Postprandial discomfort syndrome should be treated with either medication or surgery, depending on the specific trigger. If it is caused by functional dyspepsia, medication is recommended; if it is caused by organic gastrointestinal pathology, surgery is usually required. Postprandial discomfort syndrome refers to a cluster of dyspeptic symptoms such as postprandial fullness and early satiety. Different treatments can be chosen according to different triggers, as follows: 1. Pharmacological treatment: the main application of prokinetic agents, such as Itopride, through the dual mechanism of acetylcholinesterase inhibitors and dopamine receptor antagonists, has a better therapeutic effect on postprandial discomfort syndrome caused by functional dyspepsia. Meanwhile, antidepressant and anxiolytic drugs, such as buspirone and tandospirone, are also needed to improve the postprandial discomfort syndrome. 2. Surgery: If postprandial discomfort syndrome is diagnosed to be caused by organic gastrointestinal lesions, such as gastric cancer, corresponding surgery is needed to treat it, and gastric cancer patients usually need to undergo gastrectomy. Postprandial discomfort syndrome should be taken seriously, and the patient should go to regular hospitals as soon as possible for consultation, so as to clearly diagnose the specific cause of the discomfort and then go for symptomatic treatment under the guidance of doctors.