Patients with renal insufficiency can take Entecavir once every two days according to the situation, and people with normal renal function are generally recommended to take it once a day. It is recommended to take it under the guidance of the specialist doctor you visit. Entecavir is the key drug for the treatment of chronic hepatitis B virus infection, with antiviral effect, can inhibit the replication of hepatitis B virus and repair liver function. Regular dosage can achieve good results, for patients with renal insufficiency, part of it can be taken once every two days, because of the slow metabolism of the drug in the body of patients with renal insufficiency, once every two days can achieve the same antiviral treatment effect. However, for people with completely normal renal function, it is recommended to use entecavir regularly, usually once a day, not once every two days, people with normal renal function using entecavir once every two days can not reach the effective therapeutic concentration, may cause the virus to rebound, or even drug resistance.