If you need to reduce fever or pain after drinking alcohol, you should wait at least 12-24 hours, after the second day of drinking alcohol before you can go to take ibuprofen. Ibuprofen is a non-steroidal anti-inflammatory drug that inhibits the synthesis of prostaglandins to provide antipyretic and analgesic effects. This drug should not be used at the same time as alcohol, and if it is used at the same time as alcohol, it will increase the risk of gastrointestinal discomfort and liver damage and elevated transaminases. Even if you have a headache or fever after drinking alcohol, you should not use ibuprofen immediately, but wait at least 12-24 hours before considering the use of this drug. After drinking alcohol, you can consider using Chinese medicines to reduce fever and relieve pain, such as Chai Gui Fever Reducing Granules and Xiao Chai Hu Granules, which have a relatively good effect in reducing fever, and these drugs and alcohol usually do not have significant adverse reactions.