There is a risk of sequelae after a novel coronavirus infection. The sequelae are mostly seen in patients with severe and critical illnesses, while in mild and common neocoronavirus pneumonia, the prognosis is relatively good with no significant sequelae. In critically ill patients, the lung tissue may be found to be damaged to varying degrees because of the more severe degree of infection. In this case, the patient may be left with a dry cough of varying degrees and the cough may persist for some time. Patients may experience chest tightness, shortness of breath, and even hypoxemia and weakness after activity due to interstitial or fibrosis-like changes in the lung tissue, resulting in varying degrees of decreased lung function. At this time, patients should be advised to pay attention to rest, oxygen therapy, appropriate deep breathing function exercise and other treatments. Since the patient’s resistance has decreased, he or she is susceptible to infection by other pathogens at this time, and lung infection may occur again. Because of the patient’s coagulation disorder, it may induce the formation of deep vein thrombosis in the lower extremities and even lead to a significantly increased risk of pulmonary embolism. Some patients may also have sequelae of psychoneurological or loss of taste or smell sensation.