In clinical studies reported abroad, the incidence of adverse reactions to tinnitus produced by taking trazodone hydrochloride was 1.4% among hospitalized patients. There is no literature or information on the aggravation of tinnitus by taking this medication, so it is not possible to presume that the aggravation of tinnitus is related to this medication. Trazodone hydrochloride is an antidepressant medication and may cause adverse reactions such as sedation, fatigue, dry mouth, agitation, dizziness, hypotension, jaundice, anemia, thrombocytopenia, and leukopenia after administration. The drug is contraindicated in patients who are allergic to the components of trazodone hydrochloride or have severe liver dysfunction. If the symptoms of tinnitus worsen after taking this drug, it is necessary to consult a doctor in time to improve the relevant examination to clarify the cause of the disease and the extent of the symptoms. Consult an experienced licensed pharmacist and specialist as to whether adjustment of treatment or targeted disposition is required.