It is not necessary to take azithromycin or cephalosporin for groin pain, but it is first necessary to identify the cause of groin pain. A variety of factors can cause groin pain, such as bacterial infections, viral infections, inguinal hernia, varicocele, tumors, cysts, bruises and so on. If there is a mass in the affected area, it may be caused by a tumor or cyst, lipoma, etc. If the affected area is red, swollen and hot with fever, it may be caused by a pathogenic infection. In order to understand the condition, patients with groin pain need to do blood tests, examination of the affected area, color ultrasound and so on. Without clarifying the cause of the disease, azithromycin or cephalosporin should not be used blindly. If it is caused by a bacterial infection, a bacterial culture can be done for effective medication. It is important to find a sensitive antibiotic treatment. Azithromycin can cause gastrointestinal reactions such as abdominal pain, nausea, and vomiting, and antibiotics of the cephalosporin group can cause adverse reactions such as elevated aminotransferases and epigastric pain, and are contraindicated in patients who are allergic to these drugs. Pay attention to the adverse reactions and contraindications to the use of drugs. Patients with groin pain should not use azithromycin or cephalosporin on their own, they should go to the hospital in time to clarify the cause of the disease and then actively treat it, if the use of medication produces discomfort, we should actively consult the doctor.