Bupivacaine is a long-acting anesthetic preparation that generally has a better delayed effect than lidocaine. Both lidocaine and bupivacaine are two commonly used local anesthetic drugs in clinical practice, of which bupivacaine is an esterified long-acting local anesthetic drug, which also has a faster onset of action and a longer maintenance time than lidocaine. However, the dose of bupivacaine is relatively large and prone to toxic reactions, so when using bupivacaine, we must pay attention to some toxic reactions it may induce. In conclusion, lidocaine is shorter than bupivacaine in terms of its action and duration. Patients may experience increased blood levels when administered to broken or inflamed skin. Eye contact with this product should be avoided, and if eye contact occurs, the eyes should be immediately flushed with plenty of water or saline to protect them until sensation returns.