Symptoms of syphilis in the late stage will include skin and mucous membrane damage, bone and joint damage, eye damage, nerve damage, internal organ damage and so on. Syphilis patients should seek timely medical treatment, standardized treatment. 1. Skin and mucous membrane damage: there will be a highly infectious syphilis rash, which can be manifested as skin erythema, nodules, papules, plaques, etc., usually lasts for several weeks, in addition to the appearance of flat warts, which are common in the inner femur (inner thighs), the anus, the perineum, the groin, and the external genitalia and other parts of the body. 2. Bone and joint damage: Syphilis can invade the skeletal system in the later stages, leading to osteomyelitis, arthritis, periostitis, osteitis, tenosynovitis or bursitis. 3. Eye damage: vision damage can occur, including retinitis, keratitis, optic neuritis, iritis, ciliary body inflammation and so on. 4. Neurological damage: the manifestations of neurological damage mainly include asymptomatic neurosyphilis, syphilitic meningitis, cerebrovascular syphilis and so on. 5. Visceral damage: in addition, it can cause hepatitis, nephropathy and gastrointestinal tract lesions.