Having liver disease does not feet know first, there is no such thing in clinical practice. Relying on abnormal foot manifestations to determine if there is a problem with the liver can delay the condition. When liver damage is relatively mild, patients have almost no clinical symptoms and need to go to the hospital for liver biochemistry to confirm the diagnosis. The more common risk factors for liver disease in clinical practice include the following: 1, suffering from chronic disease: itself has a chronic disease, need to take long-term drug treatment, may appear drug liver damage, need to go to the hospital regularly to check liver biochemistry; 2, carrying the hepatitis B virus: itself has the hepatitis B virus infection, is in the virus carrier period, need to go to the hospital regularly to review the liver biochemistry, once elevated, need to early antiviral 3, the presence of high-risk behavior of hepatitis virus infection: such as a history of blood transfusion, tattoos, eyeliner, ear piercing, pedicure, traumatic examination or treatment, need to pay attention to the hospital for hepatitis B, hepatitis C related examination, while checking liver biochemistry; 4, long-term alcohol consumption: long-term drinkers, increased risk of liver damage, need to go to the hospital for liver biochemical examination, if there have been liver biochemical abnormalities Quit drinking as soon as possible, liver preservation treatment; 5, suffering from fatty liver: fatty liver patients need to go to the hospital regularly to check liver biochemistry, if there are abnormalities, apply liver-protective drugs for treatment, if not treated, fatty liver can also develop into cirrhosis and liver cancer. And the progression of fatty liver, more silent, patients do not have any discomfort symptoms, developed to cirrhosis, only then there are hints; 6, have a family history of hereditary metabolic liver disease: patients with a family history of hereditary metabolic liver disease need to go to the hospital as soon as possible for liver biochemical and related genetic examination. In addition to the above risk factors, if patients have weakness, loss of appetite, aversion to oil and grease, abdominal distension, and discomfort in the liver area, they should pay attention to whether there is a problem with the liver and should go to the hospital promptly for relevant examinations.