Pain in the arm after intravenous administration of azithromycin is considered to be an irritating effect of the drug on the walls of the blood vessels. In severe cases, phlebitis may even occur. Therefore, the infusion rate should be controlled during the infusion process. Because azithromycin this kind of drug belongs to the macrolide class of drugs, some patients are also prone to gastrointestinal reactions during the use of drugs, including epigastric distension or nausea and vomiting, etc., if necessary, can also be given vitamin B6 treatment. The indications for the use of the drug should be strictly controlled, especially for the elderly and children are more likely to have such adverse reactions, and some patients are even prone to allergic reactions. Azithromycin should be used with caution in patients with cardiac disease, as it may induce severe arrhythmias in some patients, so routine electrocardiograms should be performed prior to administration.