It is usually possible to have sex after taking penicillin, and it usually does not affect the effectiveness of the medicine. However, if the disease is more serious, it is not recommended to have sex. Under normal circumstances, you can have sex during penicillin injection, which will not affect the effect of the medicine and will not aggravate your condition. However, you should try to wear a condom when having sex to stop the spread of the disease and prevent cross-infection. However, if the condition is more serious and accompanied by weakness, body weakness, and other adverse reactions, try not to have sex, because this time may consume physical strength, resulting in the aggravation of the weakness. Penicillin indicates that the body may be in a state of illness, and should be avoided to consume physical strength, resulting in poor physical recovery. In the process of medication, you should go to the hospital for regular checkups and stop using it under the guidance of the doctor.