Small blisters on the hands may be caused by external irritation, eczema, sweat blisters, contact dermatitis. It is recommended to detach from the environment, give antihistamines, glucocorticoids and other drugs to eliminate. 1. External stimulation: physical stimulation of the hands, mosquito bites, resulting in localized small blisters. It is recommended to get out of the environment to avoid further aggravation of symptoms. You can use glycerin lotion to apply, which can help to reduce the symptoms. 2. Eczema: Eczema is related to external stimuli, mental stress, heredity and other factors, resulting in localized pimples and papules. Halometasone and mometasone furoate ointment can be given for topical application, which has anti-inflammatory and antipruritic effects and can control the patient’s condition. 3. Sweat herpes: sweat herpes is related to environmental factors, genetics, mental psychology, disease and other factors, can occur in the palms of the hands, feet, resulting in localized clustered blisters. Topical tretinoin urea ointment can relieve symptoms and also promote the disappearance of blisters. Small blisters on the hands may also be caused by chickenpox, hand, foot and mouth disease, herpes zoster and other diseases, it is recommended to clarify the diagnosis, corresponding to give the appropriate drug treatment. 4. Contact dermatitis: contact dermatitis can be manifested as erythema, swelling, pimples, blisters on the hands, need to identify the cause, avoid or detach from the allergic substances, can be used externally with glycerite lotion or topical tretinoin and other hormonal ointment, to alleviate the symptoms, and if necessary, can be taken orally loratadine and other anti-allergic drugs. The above drugs need to be used in accordance with medical advice. To summarize, the appearance of small blisters on the hands is related to a variety of factors. It is recommended to consult a doctor in time to clarify the cause, under the guidance of the doctor for treatment.