Most febrile patients have headache, and the headache should be analyzed or treated from its mechanism, as follows: 1. Relieve pain by lowering the temperature; 2. For patients who have headache even if their body temperature is normal during fever, antipyretic and analgesic drugs can be used at this time; 3. Fever with headache is commonly associated with intracranial infection, and its etiology should be screened. If it is caused by intracranial infection, even if the body temperature drops, the patient’s pain will not be relieved, then it is necessary to reduce the intracranial pressure, using drugs that help reduce intracranial pressure, such as mannitol and mannose to reduce intracranial pressure, thus relieving the headache; 4. In some fever with headache, a mild headache does not need to be treated, and the resting period of the body position will not be headache. Therefore, for the treatment of fever with headache, it is necessary to screen headache caused by increased intracranial pressure, because increased intracranial pressure headache often means severe disease, and brain herniation can occur, and intracranial pressure should be lowered in time.