The cure rate for patients with stage iva diffuse large b-cell lymphoma is related to many factors. Diffuse large b-cell lymphoma is a malignant tumor and the degree of cure is related to the patient’s physical condition, stage of the disease, and treatment. Diffuse large b-cell lymphoma is categorized into low-risk, intermediate-low-risk, intermediate-high-risk and high-risk. Low-risk and intermediate-low-risk patients have good treatment results, but high-risk patients have a worse prognosis. Lymphoma lesions in the iva stage will show distant metastasis to one or more organs outside the lymph nodes, which is a high-risk advanced lymphoma, and can be treated with chemotherapy-based combination therapy. Drugs include cyclophosphamide, azulpiride, vincristine, etc. Patients with larger tumors can be treated with local radiotherapy. If the treatment effect is good, it can prolong the patient’s life. It should be noted that many patients with diffuse large b-cell lymphoma may survive for a long time, and it is recommended that patients establish confidence in treatment and actively carry out standardized treatment under the guidance of doctors.