Gleevec generally refers to imatinib mesylate tablets, and symptoms such as abdominal distension, low-grade fever, false sweating, and increased white blood cells may occur when taking imatinib mesylate tablets resistant to the drug. Imatinib mesylate tablets are generally used to treat chronic granulocytic leukemia, gastrointestinal mesenchymal stromal tumors and other diseases, which have a good effect in treatment, but imatinib mesylate tablets belong to the targeted drugs, and drug resistance may occur. Usually patients will have symptoms such as increased white blood cells, splenomegaly, low-grade fever, abdominal distension, body sweating, etc. At the same time, the effect of using it to treat the disease will be affected, and it is recommended to seek medical treatment in time and consult the doctor to change the treatment method when the symptoms of drug resistance appear. When using imatinib mesylate tablets for treatment, it must be taken according to the doctor’s instructions to avoid nausea, vomiting, diarrhea and other adverse reactions, and seek medical attention as soon as possible when problems occur.