Postpartum hemorrhage cerebral edema coma may be due to irreversible neurological damage caused by severe ischemia and hypoxia, which requires active treatment, such as prompt blood transfusion and drug therapy. Postpartum hemorrhage is mainly related to weak contraction, retained placenta or fetal membrane, soft birth canal laceration, and coagulation dysfunction. Prompt blood transfusion and rehydration are needed. The duration of coma depends on the degree of hemorrhage as well as the severity of the condition, and some patients’ intelligence and memory will be affected. In severe cases, cerebral hemorrhage with pituitary ischemia may lead to Schihan’s syndrome, and even subsequent referral to the endocrinology department for specialized treatment is required. Patients with cerebral edema should take appropriate measures to lower cranial pressure during coma. The prognosis of cerebral edema is improved as much as possible by applying neurotrophic drugs. It is recommended that women with postpartum hemorrhage should be hospitalized, and after the bleeding has stopped, they should also be further observed, and if they have any discomfort, they should consult a professional obstetrician for specialized measures.