Hemofiltration replacement fluid is the replacement fluid that is applied when performing hemofiltration. Because it enters the human blood directly, it must meet sterilization requirements. The most common types are lactate-prepared replacement solution and bicarbonate-prepared replacement solution. The most commonly used replacement solution for continuous hemofiltration therapy is prepared by the department itself, and the most commonly used is composed of 0.9% sodium chloride, sterilized water for injection, glucose, potassium chloride, magnesium sulfate, calcium chloride, sodium bicarbonate, and other substances. Since sodium bicarbonate, along with other substances, may precipitate, it is dosed separately. The mechanism of action, basically convection, then achieves the removal of toxins, CRRT is continuous hemofiltration therapy, the treatment time is as short as 7 hours and as long as 24 hours. It is mainly used for resuscitation of critical illnesses, such as severe heart failure, multi-organ failure, liver failure, poisoning and other diseases.