The hazards of eating durian on an empty stomach are: 1. Durian contains a lot of sugar and heat, which can lead to increased secretion of gastric mucosa and symptoms of heartburn and acid reflux after eating durian. Patients with peptic ulcers, gastrointestinal bleeding, and acute gastric mucosal damage may experience ulcers, increased bleeding, or even gastrointestinal perforation after eating durian on an empty stomach. 2. Durian contains a large amount of potassium ions, which can stimulate the gastrointestinal tract and cause nausea and vomiting when entering the gastrointestinal tract on an empty stomach, especially in patients with chronic gastric disease who may experience gastrointestinal bleeding or peptic ulcers.