There is a relationship between lymphadenitis and staying up late. The frequent staying up late can lead to a decrease in the body’s resistance to bacterial infections, and long-term staying up late can also cause neurasthenia, endocrine disorders and other diseases. In addition, lymphadenitis is mainly related to infections, such as bacterial infections of the upper limbs, breast, chest wall and abdominal wall can cause axillary lymphadenitis; bacterial infections of the perineum, abdominal wall and lower limbs can lead to inguinal lymphadenitis; infections of the face, neck and shoulder can lead to submandibular and cervical lymphadenitis. Patients with lymphadenitis may experience localized redness, swelling, heat, and pain, as well as fever and enlarged lymph nodes. In this case, it is necessary to complete relevant examinations and apply antibiotics for anti-infection treatment under the guidance of a doctor. It is important to avoid staying up late, to ensure sufficient sleep, and to enhance nutrition to increase the body’s resistance, which will help to promote the recovery of the disease.