If patients use targeted drugs, they need to pay attention to the following aspects: 1, the digestive system commonly used targeted drugs apatinib and cetuximab and bevacizumab, attention should be paid to monitoring changes in basal blood pressure, but also frequently monitor urinary routine, the presence of uncomfortable symptoms, such as numbness in the hands and feet, rash, shortness of breath and other symptoms, if these symptoms appear, you need to communicate with your doctor in a timely manner to prevent further escalation of adverse reactions If these symptoms appear, you need to communicate with your doctor in time to prevent further escalation of adverse reactions to the point of poor control or adverse prognosis; 2. Be sure to communicate in detail with your doctor about the underlying disease, such as thrombosis or infarction, so that your doctor will consider these conditions when using the medication and then give the correct dose adjustment to use, and monitor closely, and even anytime there is discomfort, your doctor will remind further discontinuation or treatment.