Whether chemotherapy can be given to 71-year-old man with advanced lung cancer after resistance to targeted drugs should be decided according to the patient’s physical condition, and chemotherapy can be given to those who can tolerate it after comprehensive evaluation. If a 71-year-old man with advanced lung cancer is in good physical condition, has strong willingness to chemotherapy, can tolerate the adverse effects of chemotherapy drugs, and does not have serious vital organ dysfunction, he can undergo chemotherapy after resistance to targeted drugs. Chemotherapy can relieve patients’ symptoms as well as improve the quality of life and prolong the survival time. Chemotherapeutic drugs may cause bone marrow suppression, liver and kidney function impairment and other adverse reactions, 71-year-old people should be closely monitored and prevented from adverse reactions during chemotherapy. If the elderly can tolerate chemotherapy and the tumor is in remission or the disease is stable without progression after chemotherapy, maintenance therapy is feasible. Therefore, 71-year-old people with advanced lung cancer who are resistant to targeted drugs should go to the hospital in time and decide whether or not to undergo chemotherapy after the doctor’s comprehensive evaluation.