Urethral stone pain can be relieved by medications, surgical stone removal, and drinking plenty of fluids. Oral medications such as ibuprofen and acetaminophen can also be taken for relief when the pain is severe. It is recommended that patients go to the hospital in time, under the guidance of the doctor to develop a treatment plan. 1. Medication: Amoxicillin, levofloxacin and other antibiotics can be used for patients with urinary tract infections combined with urethral calculi. If the pain is severe, patients can take oral ibuprofen, acetaminophen and other drugs to relieve pain. 2. Surgical lithotripsy: according to the location of the stone, surgical treatments such as external urethral incision lithotripsy, transperineal urethral incision lithotripsy and suprapubic urethral lithotripsy can be performed. The most effective way to relieve pain from urethral stones is timely treatment. Patients should also drink plenty of fluids and flush the urethra to prevent infection. If you need to use medication, you need to use it under the guidance of your doctor.