Hashimoto’s hypothyroidism patients with fatigue, weakness and lack of energy are mainly low metabolic symptoms caused by low thyroid hormone, which can be treated with medication (thyroid hormone, glucocorticoid, etc.) and surgery. 1. Thyroid hormone: patients with Hashimoto’s hypothyroidism should be treated with thyroid hormone replacement therapy, such as levothyroxine sodium tablets, to maintain normal thyroid function. 2. Glucocorticoid therapy: Hashimoto’s thyroiditis is an autoimmune cause of hypothyroidism. When the thyroid gland is enlarged and there is localized pain or pressure symptoms, glucocorticoid therapy such as methylprednisolone can be used. 3. Surgery: When medication is ineffective or the enlargement is obvious and accompanied by compression symptoms, surgery is needed, and thyroid hormone replacement therapy is also needed after surgery. Patients with Hashimoto’s hypothyroidism are recommended to be treated under the guidance of a doctor.