Swollen hands with tight feeling when making a fist may be related to kidney disease, heart disease, trauma, rheumatoid arthritis and other factors. When suffering from renal failure and other renal insufficiency diseases, due to the loss of a large amount of protein, there can be symptoms of hand swelling, when making a fist will have a tight feeling. In cardiac insufficiency, such as heart failure, fluid retention can occur, and hand swelling may also occur with tightness when making a fist. Swelling of the hands can occur due to trauma from bacteria and other pathogens, which can lead to a feeling of tightness when making a fist. When suffering from rheumatoid arthritis, the joints of the hands can be involved, which may be manifested as swelling of the hands and a feeling of tightness when making a fist. It is recommended that people with swollen hands and tightness when making a fist go to a regular hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.