The need to take glucose-lowering medication with simepaglutide should be determined on a patient-by-patient basis. If the combination of simepaglutide and oral hypoglycemic drugs can stabilize blood glucose control, then you need to take hypoglycemic drugs; if you can stabilize your blood glucose control by taking simepaglutide alone, then you do not need to take hypoglycemic drugs. Please follow your doctor’s instructions. Simeglutide is indicated for the control of blood glucose in adults with type 2 diabetes mellitus, as well as in adults with type 2 diabetes mellitus who do not have good blood glucose control after treatment with sulfonylureas or metformin on the basis of dietary control and exercise. Adverse reactions such as nausea, diarrhea, and vomiting may occur with the use of simethicone. Combination therapy with antihyperglycemic agents is not usually necessary if patients can control their blood glucose within a reasonable range with simepaglutide alone. Patients who need to use simepaglutide or oral hypoglycemic agents should be treated under the supervision of a doctor.