The onset of action of sedative drugs is related to the drug class and also the route of action. For example, the more commonly used clinical benzodiazepine sedative sleeping drugs, are administered orally, such as diazepam, clonazepam, lorazepam, eszopiclone, alprazolam, this type of sedative sleeping drugs onset of action time, is about half an hour of taking the drug, and the duration of action is about 6-8 hours. If the patient is put to sleep by intramuscular injection of diazepam, the onset of action is very fast, and the patient may go to sleep in about 10 minutes. There are also newer sleeping drugs such as zolpidem, which may take about 15 minutes to take effect. There are also sedative drugs like chlorpromazine, which are usually injected intramuscularly in about 15 minutes, the effect will reach a stable concentration and will also take effect. The sedative drugs like midazolam will take effect in 1-2 minutes of administration.