Norfloxacin capsules and levofloxacin are different in bioavailability, antimicrobial spectrum, clinical therapeutic effects and drug metabolism. 1. Bioavailability (1) Norfloxacin capsules: the oral bioavailability of the drug is 35% to 45%. (2) Levofloxacin: the oral bioavailability of the drug is close to 100%. 2. Antibacterial spectrum (1) Norfloxacin capsules: the drug has strong antibacterial effect and is extremely effective against gram-negative bacteria. (2) Levofloxacin: the drug has a relatively wide antibacterial spectrum, effective against gram-negative bacilli, gram-positive cocci, mycoplasma, chlamydia, anaerobic bacteria and other microorganisms. 3.Clinical effects (1) Norfloxacin capsule: the drug is mainly used for gastrointestinal and urinary tract infections caused by sensitive bacteria, and can also be used externally to treat skin and eye infections. (2) Levofloxacin: the drug is used for the treatment of all kinds of acute and chronic infections and intractable infections caused by sensitive bacteria. 4.Drug metabolism (1) Norfloxacin capsule: Kidney and hepatobiliary system are the main excretion pathway, about 30% of the absorbed product is excreted in the urine in its original form, and about 30% of the absorbed product is excreted in bile or feces. (2) Levofloxacin: kidney is the main excretory route, 85% of the drug is excreted in its original form through the urine. Therefore, the two drugs are different in many ways, if you need to use the drug, please take it correctly under the guidance of a professional doctor, do not self-medication to prevent adverse effects.