The best treatment for oral herpes is the removal of systemic causative factors and local symptomatic treatment of the affected area. Oral herpes is a cutaneous mucosal disease caused by the herpes simplex virus. It is characterized clinically by the appearance of clusters of small blisters that are self-limiting and prone to recurrence. The first step is systemic antiviral treatment with oral acyclovir 200mg orally 5 times a day for 5 days; vaxilovir 1000mg orally twice a day for 10 days; and famciclovir 125mg orally twice a day for 5 days. Oral mucosa local medication: oral mucosa medication is indispensable for herpetic gingivostomatitis caused by primary herpes simplex virus infection. 0.1% to 0.2% chlorhexidine gluconate solution, compounded boric acid solution, 0.1% ezacrine solution gargle, all have antiseptic effect. 3% acyclovir ointment or phthalidone ointment local rubbing, can be used to treat herpes labialis. For tablets, chlorhexidine gluconate tablets 5mg, lysozyme tablets 20mg, cetiolide tablets 1.5mg, etc. can be used 3-4 times a day. For specific medication, please combine with the clinical, subject to the guidance of the doctor’s interview. Next is supportive therapy, usually pay attention to a balanced diet, eat more vegetables and fruits, supplement vitamins, drink more water, and strengthen physical exercise to improve immunity.