Prolonged use of Kefir has certain side effects, the current common Kefir has two preparations: one is glycerin preparation, the other is mannitol and magnesium sulfate preparation. The basic principle of these two kinds of Keseru are the same, they mainly use glycerin or sorbitol’s high concentration and high osmotic effect, by softening the stool to stimulate the intestinal wall to reflexively cause defecation reaction, coupled with the composition of the lubrication of the stool, it is also very easy to make the stool discharged. In the use of Cecrops must pay attention to the following points: First, because the skin around the anus is more delicate, the front end of the Cecrops is relatively hard, so long-term use is easy to make the mucous membrane of the perianal and rectal damage. Second, Kessel may lead to a strong contraction of local tissues, pregnant women may cause transient ischemia and chronic inflammation, while long-term use of Kessel, because of the stimulation to the intestinal wall caused by defecation reaction, often use of Kessel rectal sensitivity will gradually weaken the responsiveness to the drug will gradually weaken, will lead to a dependence on Kessel. Therefore, the long-term use of Kerosene still has a certain side effect on the human body, or should be through a healthy lifestyle to improve the stool.