With the progress of society and urbanization, the etiology of chronic glomerulonephritis and refractory nephrotic syndrome has changed greatly, and the resulting updating of treatments to address the etiology of the disease is a hot topic in the field of diagnosis and treatment of renal diseases. For refractory chronic glomerulonephritis and nephrotic syndrome, it must be excluded whether it is caused by chronic insidious mercury poisoning. Once the diagnosis of mercury poisoning-related renal damage is confirmed, mercury treatment will become the main treatment for such diseases, and the traditional hormone plus immunosuppressant treatment must be stopped, which will only increase the side effects of the treatment, aggravate the condition or make the condition more complicated. Mercury is a colorless metal, volatile at room temperature, and can be absorbed by the body through the digestive tract, respiratory tract, and surface skin contact, leading to mercury poisoning. Previously, mercury poisoning cases were mostly concentrated in the field of industrial and agricultural production, the main reason is: organic mercury compounds in pesticide production, textile, paper and part of the military field has a relatively wide range of applications, due to inadvertent operation or misuse, misuse and inhalation caused. The main clinical manifestations of acute mercury poisoning: gastrointestinal discomfort, oral lesions, neurological damage, renal damage, myocarditis, hepatic function involvement, and local contact site lesions such as contact dermatitis, conjunctivitis, corneal edema. Chronic mercury poisoning begins with toxic neurasthenia syndrome, as well as numbness and tingling sensation of the tongue, lips, ends of the limbs, tremor of the limbs, insomnia, malaise, proteinuria, lethargy, swelling, etc., and the progression of the disease can be characterized by a large amount of proteinuria, hypertension, and impaired renal function. Clinical data in recent years show that: mercury poisoning performance is hidden, many patients with glomerulonephritis, nephrotic syndrome is through repeated careful questioning to learn that its recent use of whitening cosmetics, hair dyes, diet pills history, some patients have contact with the “Cordyceps sinensis”, traditional Chinese medicine fumigation, a certain ancestral recipe, some of them are engaged in panning for gold, Some patients have contact with “Cordyceps sinensis”, fumigation of traditional Chinese medicine, some ancestral recipes, etc. Some of them are engaged in gold panning and mining, and some of them have unknown medical history, but the blood and urine toxicity tests clearly indicate that the blood and urine mercury are significantly over the standard, and their condition can be cured after mercury treatment. At present, there are not many reports of mercury poisoning related kidney damage abroad, but there are a lot of patients with mercury poisoning in our country. There are many reasons leading to this status quo, such as counterfeit and shoddy products, unscrupulous traders driven by economic interests in the precious Chinese medicine ingredients, some of the people’s poor lifestyle, etc. We should not be afraid of “losing face”, and we should not be afraid of “losing face”. We should not dilute the in-depth study of mercury poisoning-related kidney damage for fear of “shame”, but should continue to redouble our efforts to increase the popularization of science, so that the whole society, even foreigners, can understand the dangers, with a view to early diagnosis and treatment for the benefit of the whole world. It is also hoped that the relevant functional departments will strengthen their control over the source of mercury to prevent more people from coming into contact with this “invisible killer”. Mercury poisoning-related toxicity testing has become a routine test in the process of diagnosis and treatment of refractory nephrotic syndrome and chronic glomerulonephritis in the Department of Nephrology of the hospital, and the specimens are sent to the toxicity laboratory of the People’s Liberation Army (PLA) 307 Hospital. According to the incomplete statistics of Dr. Su from the Department of Nephrology of Peking University Hospital, mercury toxicity-related renal damage accounts for 5-20% of the causes of such diseases, and mercury toxicity-related factors account for an even higher percentage of kidney disease patients who have used whitening cosmetics for a long period of time or who have received long-term whitening and slimming services from unscrupulous beauty salons! This data is alarming and unexpected by almost everyone. What is more worrying is that the majority of doctors, even professional nephrologists do not know enough about this new situation, and the majority of hospitals do not carry out routine mercury poisoning related toxicity testing, many typical mercury poisoning related kidney damage can not get timely and accurate treatment, patients often bounced around in a number of hospitals, and according to common nephritis nephropathy treatment program for a long time, never effective, and even to the point of Even after various complications or uremia, the real cause of the disease has not been clarified, and the use of regular and accurate mercury treatment for the cause of the disease is even more difficult to talk about. Patients diagnosed with mercury poisoning related kidney damage, the treatment effect is very good, after the end of mercury, protein conversion rate is more than 50%, after 3 months of follow-up, urine protein conversion rate can reach more than 90%, and free from hormone and immunosuppressant treatment. Appeal: please join hands with the whole society to pay attention to mercury poisoning, attention to mercury poisoning caused by glomerulonephritis, nephrotic syndrome; once mercury poisoning manifestation of nephrotic patients themselves, should learn to save themselves, must be clear or excluded after blood and urine toxicity test is mercury poisoning related, your a small step in exchange for a big step for yourself and your family.