Intacin, the generic name of which is diclofenac sodium extended-release capsules, is not recommended to be taken together with ibuprofen to avoid causing adverse reactions. Diclofenac sodium extended-release capsules and ibuprofen belong to the same non-steroidal anti-inflammatory drugs, with anti-inflammatory and analgesic effects, the same kind of drugs taken together, may lead to drug overdose and induce adverse reactions, affecting health. Diclofenac sodium extended-release capsules are used to relieve osteoarthritis and rheumatoid arthritis and other chronic inflammation in the acute exacerbation or persistent arthralgia, as well as a variety of soft-tissue rheumatism pain medication, the more common adverse reactions, including headache, drowsiness, euphoria, vertigo, and edema, lactation and pregnancy is prohibited for women. Ibuprofen is used to relieve mild to moderate pain, such as headache, muscle pain, and neuralgia, etc. Common adverse effects include nausea, vomiting, bleeding, and headache, etc. It is contraindicated for non-steroidal anti-inflammatory drugs (NSAIDs), and for pregnant and lactating women. In addition, there are certain risks associated with the use of the above medications, and patients need to be guided by a specialist.