The edge of the tongue has raised bumps of flesh very painful may be caused by mechanical stimulation, may also be the emergence of tongue papillitis, tongue polyps and other diseases, you can carry out drug treatment or surgical treatment. 1. Mechanical stimulation, if you do not pay attention to personal diet, often eat spicy and stimulating food, may lead to mechanical stimulation of the tongue, so there will be such symptoms, generally do not need to use drugs to treat, usually can eat more light and nutritious food. If you are afraid of infection, you can use amoxicillin, cefixime and other anti-inflammatory drugs under the guidance of a doctor. 2. papillitis of the tongue, patients with papillitis of the tongue due to inflammatory stimulation of the tongue, may lead to such symptoms, you can use metronidazole, cefuroxime and other drugs. 3. Tongue polyps, if caused by tongue polyps on the edge of the tongue with raised bumps of flesh is very painful, you can choose to carry out surgical resection, completely remove tongue polyps. Usually need to pay attention to personal oral hygiene, regular medical review.