If the headache occurs at night, it may be caused by paranasal sinusitis, mainly seen in maxillary sinusitis or mandibular sinusitis.1. The main treatment is anti-inflammatory, commonly used drugs include ceftriaxone sodium, cefoperazone sulbactam, and at the same time can be added with tinidazole, metronidazole or ornidazole for anti-inflammatory treatment. If the patient is chronic, puncture irrigation treatment can also be considered, and if necessary, surgery can be considered.2. If the patient has severe headache, symptomatic pain medications can also be applied, including ibuprofen, indomethacin, naproxen and acetaminophen, etc. It may also be caused by primary headache diseases, such as cluster headache, which is a kind of primary neurovascular headache. 3. Patients mainly show persistent drilling pain, pulling and tearing pain in the periorbital area or frontotemporal area of one side of the eye, and can also appear colic, etc. Most patients have the onset at night, probably more often 1-2 hours after going to sleep, and the symptoms of patients can last 15-180 minutes. The patient’s symptoms can last from 15 to 180 minutes and can stop abruptly or be slowly relieved, mainly with symptomatic analgesic treatment, such as zolmitriptan and sumatriptan.