Small blisters on the nostrils can be associated with diseases such as herpes simplex, nasal vestibular eczema or atopic dermatitis. 1. Herpes simplex: it is caused by herpes simplex virus infection, which can be infected by living in close contact, and can cause small blisters to appear in many parts of the nose, perinasal area, mouth and lips in an aggregated manner, which can break down and become shallow ulcers. 2. Nasal vestibule eczema: under the effect of internal and external factors such as psychoneurological factors, genetic factors, pollen and other inhalants or animal fur, erythema, papules, blisters and intense itching can appear on the face. 3. Atopic dermatitis: caused by genetic as well as environmental factors, when occurring in infancy, itchy erythema on the face will appear, and then become papules, blisters and other lesions, scratching and friction can lead to oozing and crusting. The appearance of small blisters in the nostrils, it is recommended to seek medical attention in a timely manner, follow the doctor’s instructions for treatment, and at the same time avoid scratching.