Pain in the middle of chest when drinking water may be caused by reflux esophagitis, esophageal cancer, improper water temperature and so on. 1. Reflux esophagitis: As stomach contents flow back into the esophagus, it can cause damage to the esophageal mucosa, and when drinking water, it can stimulate the damaged area, which can cause pain in the middle of chest. 2. Esophageal cancer: if esophageal tumor cells invade the tissues outside the esophagus, it may cause pain in the middle of chest when drinking water. 3. Improper water temperature: If the water temperature is too high, it can cause the esophageal mucosa to be hurt, which may cause pain in the middle of the chest. It is recommended that people who have pain in the middle of the chest when drinking water should go to the hospital in time, clarify the cause of the disease, and carry out standardized treatment under the guidance of the doctor.