Whether or not a high-risk HPV positive test is serious depends on the condition. If the patient is only high-risk HPV positive, it is usually not serious. If the patient is high risk HPV positive, accompanied by cervical lesions or cervical cancer, then it is more serious. It is recommended that patients with high-risk human papillomavirus positivity, need to timely do thin-layer cytology examination, if the patient’s examination results are normal, it is mostly considered that the patient has pure high-risk human papillomavirus positivity, at this time, the condition is not serious, but the patient should go to the hospital for review on a regular basis. If the results of thin-layer cytology test indicate cervical intraepithelial neoplasia or cervical cancer, the condition is more serious. It is recommended that patients with high risk HPV positivity should consult a doctor in time, and the doctor will judge whether the condition is serious or not according to the patient’s condition, and will take appropriate treatment measures. In addition, patients should keep the perineum clean and avoid having unclean sex.