Paroxysmal pain in the right upper abdomen is most commonly caused by liver and gallbladder diseases, costal cartilage problems, intercostal neuralgia and pleural lesions. 1. Liver and gallbladder problems: the most common ones are cholecystitis, gallbladder stones, hepatitis, cirrhosis, and tumor lesions of the liver and gallbladder, all of which may lead to paroxysmal pain. Clinical examination, laboratory tests, imaging tests, etc., can clarify the diagnosis and provide appropriate treatment. 2. Rib cartilage problem: the process of rib cartilage ossification will cause local dull pain and discomfort, avoid repeated stimulation, and it will gradually heal itself. If the pain is aggravated, oral painkillers can be used. 3. Intercostal neuralgia: it is related to infection and trauma, and can cause referred pain, which can be treated with oral ibuprofen, diclofenac sodium and other drugs. Inflammation can be oral amoxicillin, cefaclor and other antibiotics anti-inflammatory treatment. Simple nerve pain can be applied to nutritional nerve drugs, generally can be applied to methylcobalamin. 4. Pleurisy: pleural adhesion stimulation of local nerves can also cause pain in the corresponding parts, acute inflammation can be applied to moxifloxacin and other anti-infective treatment. Chronic pleurisy, the pain is obvious can apply painkillers, such as ibuprofen. Right upper abdominal pain is severe and difficult to relieve, need to consult a doctor in time for observation. Drugs should be applied under the guidance of a doctor.