A severe case of tongue hypertrophy with teeth marks needs to be treated according to the cause. Possible causes include repeated friction, trauma, chronic diseases, etc. Treatment includes no treatment, medication, and treatment of underlying chronic diseases. 1. The main reason for the seriousness of tongue hypertrophy and teeth marks is the repeated friction between the tongue and the surrounding teeth, which will result in teeth marks. If there are no symptoms, no special treatment is needed. 2. After the tongue suffered trauma, the tongue will become hypertrophied, and the surrounding teeth friction frequency increases so that the teeth marks, this time should go to the local medical institutions in time to clean up the trauma, if necessary, should take the appropriate drugs anti-inflammatory and analgesic, such as amoxicillin, erythromycin and other drugs. 3. Long-term patients suffering from certain chronic diseases, such as renal failure, uremia and other diseases, the body’s long-term consumption will lead to tongue hypertrophy, friction with the teeth to increase the appearance of tooth marks, this time you should contact the attending physician for the corresponding treatment of chronic diseases. Tongue hypertrophy teeth marks serious there may be other reasons, it is recommended that the hospital to identify the causes, under the guidance of the doctor to give targeted treatment, the above mentioned medication should be used under the guidance of a doctor, avoid self-medication.