Joint pain in the limbs may be caused by cold and fever, overwork, joint disease, osteoporosis, metabolic bone disease. 1. Cold and fever: pathogens release toxins and inflammatory mediators in the body, stimulating nerve endings and thus producing pain. Metabolism is accelerated during high fever, resulting in relative hypoxia, and anaerobic fermentation is strengthened, generating more lactic acid, the accumulation of lactic acid can cause joint pain. 2. Overwork: prolonged strenuous labor may lead to excessive friction of articular cartilage, which may also cause synovial inflammation around the joints, thus causing joint pain. 3. Joint diseases: including rheumatoid arthritis, rheumatoid arthritis, degenerative osteoarthropathy and so on. Rheumatoid arthritis causes autoimmune joint pain. Rheumatoid arthritis causes wandering polyarthritis. Degenerative osteoarthropathy causes degenerative joint cartilage lesions and secondary osteophytes. 4. Osteoporosis: Osteoporosis patients mostly have pain in the thoracolumbar spine, and the aggravation of the disease in the later stage may lead to pain in the weight-bearing joints such as the knee joints and ankle joints. It mostly occurs in middle-aged and old people, especially in postmenopausal women. 5. Metabolic bone disease: including gout, vitamin D metabolism disorder. Gout is a recurrent inflammatory disease caused by the deposition of urate crystals in synovial membrane, cartilage and other tissues. Vitamin D metabolism disorder leads to osteochondrosis osteoarthropathy. Other causes of joint pain in the limbs may be trauma, soft tissue diseases, allergic purpura, bone and joint tumors, and so on. If the rest can not be relieved, it is recommended to go to a regular hospital in a timely manner, by the doctor to clarify the cause of the disease, to give targeted treatment.