Ankylosing spondylitis sleeping back pain waking up does not hurt, this statement is not accurate, it should be obvious that the pain at night when sleeping, waking up after the activity is no longer painful, this is ankylosing spondylitis local soft tissue inflammatory adhesion caused. The first symptom of ankylosing spondylitis is often lower back pain with morning stiffness, which can also be manifested as unilateral, bilateral or alternating soreness radiating from the buttocks and groin to the lower limbs, etc. The first symptom of ankylosing spondylitis is often lower back pain with morning stiffness. The pain symptoms have regularity, that is, the pain is obvious when sleeping at night, and no longer pain or pain relief after waking up and moving around, which is caused by local soft tissue inflammatory adhesions in ankylosing spondylitis. Patients with severe low back pain can be treated with NSAIDs such as celecoxib, which can rapidly improve low back pain and stiffness, reduce joint swelling and pain, and increase range of motion. Once ankylosing spondylitis develops, it is necessary to consult a rheumatologist in a timely manner, follow the doctor’s instructions for treatment, and follow the doctor’s instructions for regular follow-ups in order to better control the disease.