Cold precipitate is rich in fibrinogen, vascular hemophilia factor, factor VIII, factor XIII and fibrin-binding protein, so its main use is for supplementation of factor VIII and fibrinogen, and it is used in patients with mild hemophilia A and vascular hemophilia. Cryoprecipitate is a white precipitate obtained by melting fresh frozen plasma at 4°C, leaving only a small amount of ice residue, and centrifuging it at 3000g for 10 minutes. One unit of fresh frozen plasma yields approximately 25 mL of cold precipitate, or one unit. Perioperative fibrinogen should be maintained at a minimum of 1-1.5 g/L, at which point the amount of cold precipitate supplementation should be determined based on the amount of blood leaking or bleeding from the wound. One unit of cold precipitate contains approximately 250 mg of fibrinogen, and supplementation with 20 units of cold precipitate will restore the body to the surgically required fibrinogen level of 1-1.5 mg/L. In the presence of severe postoperative wound bleeding and massive blood transfusion, when fibrinogen concentration cannot be measured in time or when fibrinogen concentration is below 0.8-1g/L, cold precipitate should be infused.