Patient Wang, female, 56 years old, the patient was admitted to the hospital for generalized pain, admission examination: generalized muscle and joint pressure of widespread pain. Admission symptoms of the patient’s mood pessimism, depression, through the general anti-inflammatory analgesic and physical therapy is ineffective, and then through the depression scores, consider depressive polypain, given antidepressant medication for 2 weeks, the patient’s generalized pain disappeared, cured and discharged. Discussion: generalized pain disease, for general doctors may not be able to start, may consider rheumatoid arthritis, rheumatoid myalgia syndrome and other diseases, but through the rheumatism of some patients, we can change the idea of treatment, it may be the scene of the darkness of the flowers, in the treatment of pain disease, in fact, a large proportion of the patients are present in different degrees of depression, through the Chinese medicine of liver detoxification and depression, strengthening the spleen, and the treatment of depression. Through the traditional Chinese medicine of detoxifying the liver and resolving depression, strengthening the spleen and nourishing the blood, and the antidepressant treatment of western medicine, satisfactory curative effects have been achieved.