Swelling and pain in the big toe of the foot can be caused by an onychomycosis or by gouty nodules. Inguguinitis pain is on the outside or inside of the toenail and is a bacterial infection. The cause is mainly due to the growth of the toenail to the sides into the surrounding tissues, which leads to bacterial infection of the surrounding tissues and the appearance of redness, swelling, hardness and pus. For the treatment of onychomycosis, the abscess should be cut open and the pus drained out. If the abscess spreads to the underside of the toenail, simple incision and drainage of the pus will result in poor drainage and the toenail will need to be removed. Gouty nodules manifested in the root of the big toe, usually mainly lateral, red nodules, pain is very obvious, mainly because of purine metabolism abnormality caused by the patient’s body uric acid increased and caused. Need oral allopurinol to carry on the treatment, and in the process of treatment can not drink beer, also can not eat seafood and so on.