Multiple diverticula of the ascending colon is a common intestinal disease in clinical practice, which refers to the occurrence of multiple depressions of the gastrointestinal mucosa in different parts of the colon. Multiple diverticula of the ascending colon are mainly caused by increased pressure in the colon and are categorized into congenital diverticula and acquired diverticula. Congenital diverticulum is the congenital weakness of the whole layer of the colon wall; acquired diverticulum is due to the increased pressure in the intestinal lumen, which may be related to the low-fiber diet, such as the patient’s long-term constipation, low intake of fruits and vegetables, and so on, which will increase the pressure in the colon. Patients with mild symptoms of multiple diverticula of the ascending colon do not need treatment. They should pay attention to adjusting their lifestyle, eating a healthy diet, eating more fruits and vegetables, and keeping their bowel movements smooth. Patients with severe symptoms of multiple diverticula of the ascending colon can choose surgical treatment, and it is recommended to consult a doctor in time for targeted treatment under the guidance of the doctor.