The prevention and treatment of cerebral white matter degeneration varies according to the cause of the disease. 1. Cerebral white matter degeneration caused by cerebrovascular factors: Diseases such as hypertension, diabetes mellitus and hyperlipidemia may affect the small blood vessels of the brain. Prolonged hypoperfusion of brain tissue may lead to cerebral white matter lesions. These patients should actively control the primary disease. Treatment can be carried out by taking drugs such as aspirin which is anti-platelet and atorvastatin which stabilizes atherosclerotic plaque. 2. Cerebral white matter degeneration caused by neurological diseases: such as multiple sclerosis, optic nerve myelitis and other demyelinating lesions of the nervous system. These diseases are mainly related to heredity, poor lifestyle, and immune dysfunction. So prevention is done by regular living and avoiding infections. Treatment is mostly with hormonal drugs such as methylprednisolone and immunosuppressive drugs such as azathioprine and methotrexate. If white matter degeneration of the brain has been diagnosed in the hospital, it is important to follow the doctor’s instructions and treat accordingly.