Chronic renal failure stage III is mainly conservative treatment, including treatment of primary disease, nutritional therapy, anti-infection, symptomatic treatment to prevent complications. 1. Treatment of primary disease: patients with chronic renal failure stage III usually have primary disease such as hypertension, diabetes, etc. Drugs such as nifedipine and metformin should be given to alleviate the symptoms of primary disease. After active treatment, the progress of renal function damage can be significantly delayed, and even improved to a certain extent. 2. Nutritional therapy: According to the patients’ renal function status, reducing the amount of dietary protein or implementing a low-protein diet is the key to nutritional therapy. From stage 3, the recommended protein intake is 0.6g/(kg.d), and essential amino acids or compound a-keto acids can be supplemented to avoid negative nitrogen balance. 3. Anti-infective treatment: those with infections can be treated with non-nephrotoxic or low-toxicity antibiotics, such as levofloxacin, cefoperazone, etc., and the dosage of the drugs can be adjusted according to the glomerular filtration rate. 4. Symptomatic treatment: patients may have itchy skin, emulsified oil should be given to apply, if hyperlipidemia occurs, statin drugs can be taken, such as Rosuvastatin, simvastatin, etc.. For patients with chronic renal failure stage III, they should consult the doctor in time and actively cooperate with the doctor’s treatment to prevent the condition from deteriorating.