The stomach around three o’clock in the morning uncomfortable to consider is duodenal ulcer, stomach cramps, acute gastroenteritis and other disease factors; need to be under the guidance of the doctor for targeted treatment, such as general treatment, medication and so on. 1. duodenal ulcer: typical symptoms of hunger pains, night pains, pain attacks can be relieved by eating properly; can also be prescribed the use of cimetidine, omeprazole and other medications, Rebapatide and other gastric mucosal protectants, domperidone and other gastric motivation drugs. 2. Stomach cramps: overeating, eating too much cold stimulating food, sleep at night during the process of not paying attention to abdominal warmth, caused by stomach cramps, you can use pivacidium bromide antispasmodic pain treatment, while paying attention to abdominal warmth. 3. Acute gastroenteritis: after eating unclean food at dinner may lead to stomach discomfort around 3:00 a.m., combined with bacterial infection can take ciprofloxacin treatment, diarrhea symptoms can be taken when serious loperamide treatment, abdominal pain is serious can take scopolamine treatment. It is recommended that you go to the hospital when you have an upset stomach around 3:00 a.m. and ask your doctor to make a judgment and identify the cause of the problem.