In 1909, Babcock firstly proposed the concept of chole-heartsyndrome, and in 1933, Mclemore et al. proved through practice and clinic that dilation of gallbladder could lead to angina pectoris, which was thought to be the result of vagal reflexes, and it was called “reflex angina pectoris. “In 1977, BNHOTPaâ…¡OB pointed out that the cause of cardiac dysfunction in patients with biliary diseases not only has the characteristic of reflex, but also affected by various metabolic factors, and suggested the name of “biliary heart syndrome”. Since the 1980s, due to the high incidence of bile duct and gallbladder diseases, bile-cardiac syndrome is not uncommon in the clinic. With the change of people’s dietary structure, the incidence of biliary diseases increases year by year, and bile-cardiac syndrome also increases, and has a tendency of low age. Biliary-cardiac syndrome refers to patients with biliary tract disease who have transient signs and symptoms of coronary heart disease, which often occurs along with the acute attack of biliary tract disease, and disappears automatically after the biliary disease is relieved. Patients with biliary heart syndrome do not have organic lesions of the coronary arteries, and can be expected to return to normal after biliary disease is cured. The incidence of women is more than men. According to the cause of the disease to do the appropriate prevention. Clinical practice has proved that after internal or surgical treatment of biliary diseases, the symptoms of coronary heart disease can be cured and the electrocardiogram will gradually return to normal. Regarding the treatment of bile-cardiac syndrome, the first step is to remove the biliary tract disease, and after the biliary tract disease is removed, the abnormal heart function can be relieved or disappeared. However, special attention should be paid to the presence of primary organic cardiovascular disease in the treatment of biliary-cardiac syndrome. If there is such a disease, it should be closely coordinated with medical treatment, and surgical treatment should be performed to remove the biliary disease if the patient can tolerate the surgery.