High indirect bilirubin can be seen in hemolytic, hepatocellular, cholestatic jaundice and some cases of congenital non-hemolytic jaundice. Indirect bilirubin, also known as unconjugated bilirubin (UCB) or free bilirubin, has a normal value of 1.7-10.2 μmol/L, with 26 μmol/L indicating elevated indirect bilirubin. Elevated indirect bilirubin can be seen in congenital hemolytic anemia such as marine anemia, hemolytic anemia such as neonatal hemolysis and autoimmune hemolysis, and the bilirubin elevation is dominated by the elevation of indirect bilirubin; it can also be seen in viral hepatitis, cirrhosis and other hepatocellular injuries resulting in hepatocellular jaundice, and the indirect bilirubin is mostly moderately increased. Indirect bilirubin is also elevated in cholestatic jaundice due to primary biliary cirrhosis, choledocholithiasis, etc., which is usually only mildly elevated, and in congenital non-hemolytic jaundice, such as Gilbert’s syndrome. Indirect bilirubin can be elevated in many types of jaundice. To determine the cause of jaundice, it is necessary to combine direct bilirubin and total bilirubin, etc. It is recommended that the patient consults with a specialist, and combines this with other examination reports for a comprehensive analysis and judgment.